Article

Semaphorin 3A reduces the severity of aGVHD by promoting M2 macrophage polarization

2026-02-11

Abstract excerpt

<title>Abstract</title> <p>Acute graft-versus-host disease (aGVHD) remains a serious complication allogeneic hematopoietic stem cell transplantation (allo-HSCT) and significantly impacts nonrelapse mortality (NRM). While Semaphorin 3A (Sema3A) is implicated in immune regulation during inflammatory conditions, its role in aGVHD pathogenesis was unclear. Using an aGVHD mouse model, intravenous recombinant Sema3A ad...

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Literature Corpus work: 5a08d58f-6f78-5fda-8911-209a295830ec
DOI: 10.21203/rs.3.rs-7904342/v1

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