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Article

Macrophage polarization toward M1 phenotype through NF-κB signaling in patients with Behçet's disease.

Arthritis research & therapy - 4 Nov 2022

Wu Xiuhua, Wang Zhimian, Shi Jing, Yu Xin, Li Chaoran, Liu Jinjing, Zhang Fengchun, Chen Hua, Zheng Wenjie

Abstract excerpt

BACKGROUND: Macrophages are key innate immune cells implicated in the pathogenesis of Behçet's disease (BD), and macrophage polarization plays a pivotal role in inflammatory response. This study aimed to investigate the role of BD serum on the phenotypes and functions of macrophage polarization. METHODS: BD or HC serum-treated human monocyte-derived macrophages (HMDMs) were examined M1/M2 phenotypes using flow...

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Identifiers

PMID: 36333776
DOI: 10.1186/s13075-022-02938-z
PMCID: PMC9635113

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