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Article

hUC-EVs-ATO reduce the severity of acute GVHD by resetting inflammatory macrophages toward the M2 phenotype.

Journal of hematology & oncology - 21 Jul 2022

Su Yan, Sun Xueyan, Liu Xiao, Qu Qingyuan, Yang Liping, Chen Qi, Liu Fengqi, Li Yueying, Wang Qianfei, Huang Bo, Huang Xiao-Jun, Zhang Xiao-Hui

Abstract excerpt

BACKGROUND: Both extracellular vesicles from mesenchymal stromal cell-derived human umbilical cords (hUC-EVs) and arsenic trioxides (ATOs) have been demonstrated to treat acute graft-versus-host disease (aGVHD) via immunomodulation. Apart from immunomodulation, hUC-EVs have a unique function of drug delivery, which has been proposed to enhance their efficacy. In this study, we first prepared ATO-loaded hUC-EVs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35864538
DOI: 10.1186/s13045-022-01315-2
PMCID: PMC9306027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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