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Article

An SNP in protamine 1: a possible genetic cause of male infertility?

30 Sept 2005

Abstract excerpt

Gene targeting of the sperm nuclear proteins, the protamines, in mice leads to haploinsufficiency, abnormal chromatin compaction, sperm DNA damage, and male infertility. In order to investigate whether changes in amount or structure of the protamines could be a cause of human infertility, we sequenced the protamine genes of infertile men whose sperm appeared phenotypically similar to those of protamine deficient...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16199539
DOI: 10.1136/jmg.2005.037168

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

An SNP in protamine 1: a possible genetic cause of male infertility?PMID 16199539Read ↗

A common protamine 1 promoter polymorphism (-190 C->A) correlates with abnormal sperm morphology and increased protamine P1/P2 ratio in infertile patients.Semantic proximity Read ↗

Mutations in the protamine 1 gene associated with male infertilitySemantic proximity Read ↗

Haploinsufficiency of protamine-1 or -2 causes infertility in mice.Semantic proximity Read ↗

Protamine alterations in human spermatozoa.Semantic proximity Read ↗

Mutations in the protamine locus: association with spermatogenic failure?Semantic proximity Read ↗

Single nucleotide polymorphisms in the protamine-1 and -2 genes of fertile and infertile human male populations.Semantic proximity Read ↗

Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1Semantic proximity Read ↗

Viable offspring obtained from Prm1-deficient sperm in miceSemantic proximity Read ↗

The aetiology of sperm protamine abnormalities and their potential impact on the sperm epigenome.Semantic proximity Read ↗

A common haplotype of protamine 1 and 2 genes is associated with higher sperm counts.Semantic proximity Read ↗

Loss of <i>Prm1</i> leads to defective chromatin protamination, impaired PRM2 processing, reduced sperm motility and subfertility in male miceSemantic proximity Read ↗

Polymorphisms, haplotypes and mutations in the protamine 1 and 2 genesSemantic proximity Read ↗

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