Article
Clonal hematopoiesis in donors and long-term survivors of related allogeneic hematopoietic stem cell transplantation.
Blood - 30 Apr 2020
Boettcher Steffen, Wilk C Matthias, Singer Jochen, Beier Fabian, Burcklen Elodie, Beisel Christian, Ventura Ferreira Monica S, Gourri Elise, Gassner Christoph, Frey Beat M, Schanz Urs, Skoda Radek C, Ebert Benjamin L, Brummendorf Tim H, Beerenwinkel Niko, Manz Markus G
Abstract excerpt
Clonal hematopoiesis (CH) is associated with age and an increased risk of myeloid malignancies, cardiovascular risk, and all-cause mortality. We tested for CH in a setting where hematopoietic stem cells (HSCs) of the same individual are exposed to different degrees of proliferative stress and environments, ie, in long-term survivors of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and their...
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