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CD56neg CD16+ cells represent a distinct mature NK cell subset with altered phenotype and are associated with adverse clinical outcome upon expansion in AML.

Frontiers in immunology - 1 Jan 2024

Wlosik Julia, Orlanducci Florence, Richaud Manon, Demerle Clemence, Amara Amira Ben, Rouviere Marie-Sarah, Livrati Philippe, Gorvel Laurent, Hospital Marie-Anne, Dulphy Nicolas, Devillier Raynier, Vey Norbert, Olive Daniel, Chretien Anne-Sophie

Abstract excerpt

Introduction: Acute myeloid leukemia (AML) is a rare haematological cancer with poor 5-years overall survival (OS) and high relapse rate. Leukemic cells are sensitive to Natural Killer (NK) cell mediated killing. However, NK cells are highly impaired in AML, which promote AML immune escape from NK cell immune surveillance. We made the first report of CD56neg CD16+ NK cells expansion in AML. This unconventional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39867888
DOI: 10.3389/fimmu.2024.1487792
PMCID: PMC11760599

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