Article

Untargeted urinary metabolomics by CREBRF rs373863828 (p.Arg457Gln) variant among individuals without type 2 diabetes

2025-05-13

Abstract excerpt

<title>Abstract</title> <p><bold>Background/Objectives</bold>: The CREBRF rs373863828-A (p.Arg457Gln) variant is associated with increased body mass index (BMI) but paradoxically reduced odds of type 2 diabetes (T2D). This study used untargeted urinary metabolomics to investigate metabolic pathways influenced by the <italic>CREBRF</italic> variant in Māori and Pacific peoples without T2D. <bold>Methods</bold>: Un...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 59f1a537-690d-5378-9db8-9e05e6e8fe92
DOI: 10.21203/rs.3.rs-6372155/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Untargeted urinary metabolomics by CREBRF rs373863828 (p.Arg457Gln) variant among individuals without type 2 diabetesDOI 10.21203/rs.3.rs-6372155/v1Read

Meta-Analysis of Urinary Metabolite GWAS Studies Identifies Three Novel Genome-Wide Significant LociSemantic proximity Read

Integrative metabolomics and genomics reveal molecular signatures for type 2 diabetes and its cardiovascular complications.Semantic proximity Read

A genome-wide association study of metabolic traits in human urine.Semantic proximity Read

An exome array study of the plasma metabolome.Semantic proximity Read

Genome-Wide Association Study with Targeted and Non-targeted NMR Metabolomics Identifies 15 Novel Loci of Urinary Human Metabolic Individuality.Semantic proximity Read

Genome-wide characterization of 54 urinary metabolites reveals molecular impact of kidney function.Semantic proximity Read

Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links.Semantic proximity Read

The role of genetic variation of human metabolism for BMI, mental traits and mental disorders.Semantic proximity Read

A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.Semantic proximity Read

Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand.Semantic proximity Read

Urinary metabolites along with common and rare genetic variations are associated with incident chronic kidney disease.Semantic proximity Read

Genome-wide characterization of 54 urinary metabolites reveals molecular impact of kidney functionSemantic proximity Read