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Article

An exome array study of the plasma metabolome.

Nature communications - 25 Jul 2016

Rhee Eugene P, Yang Qiong, Yu Bing, Liu Xuan, Cheng Susan, Deik Amy, Pierce Kerry A, Bullock Kevin, Ho Jennifer E, Levy Daniel, Florez Jose C, Kathiresan Sek, Larson Martin G, Vasan Ramachandran S, Clish Clary B, Wang Thomas J, Boerwinkle Eric, O'Donnell Christopher J, Gerszten Robert E

Abstract excerpt

The study of rare variants may enhance our understanding of the genetic determinants of the metabolome. Here, we analyze the association between 217 plasma metabolites and exome variants on the Illumina HumanExome Beadchip in 2,076 participants in the Framingham Heart Study, with replication in 1,528 participants of the Atherosclerosis Risk in Communities Study. We identify an association between GMPS and...

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Identifiers

PMID: 27453504
DOI: 10.1038/ncomms12360
PMCID: PMC4962516

Genes

GMPS
HAL
PAH
UPB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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