A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.

doi:10.1371/journal.pgen.1002270

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Article

A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.

PLoS genetics - 1 Sept 2011

Nicholson George, Rantalainen Mattias, Li Jia V, Maher Anthony D, Malmodin Daniel, Ahmadi Kourosh R, Faber Johan H, Barrett Amy, Min Josine L, Rayner N William, Toft Henrik, Krestyaninova Maria, Viksna Juris, Neogi Sudeshna Guha, Dumas Marc-Emmanuel, Sarkans Ugis, Donnelly Peter, Illig Thomas, Adamski Jerzy, Suhre Karsten, Allen Maxine, Zondervan Krina T, Spector Tim D, Nicholson Jeremy K, Lindon John C, Baunsgaard Dorrit, Holmes Elaine, McCarthy Mark I, Holmes Chris C

Abstract excerpt

We have performed a metabolite quantitative trait locus (mQTL) study of the (1)H nuclear magnetic resonance spectroscopy ((1)H NMR) metabolome in humans, building on recent targeted knowledge of genetic drivers of metabolic regulation. Urine and plasma samples were collected from two cohorts of individuals of European descent, with one cohort comprised of female twins donating samples longitudinally. Sample...

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PMID: 21931564
DOI: 10.1371/journal.pgen.1002270
PMCID: PMC3169529

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NAT8
PYROXD2

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