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Integrative metabolomics and genomics reveal molecular signatures for type 2 diabetes and its cardiovascular complications.

Cardiovascular diabetology - 16 Apr 2025

Cheng Chunxiao, Liu Yuanjiao, Sun Lingyun, Fan Jiayao, Sun Xiaohui, Zheng Ju-Sheng, Zheng Lin, Zhu Yimin, Zhou Dan

Abstract excerpt

BACKGROUND: Metabolites are pivotal in the biological process underlying type 2 diabetes (T2D) and its cardiovascular complications. Nevertheless, their contributions to these diseases have not been comprehensively evaluated, particularly in East Asian ancestry. This study aims to elucidate the metabolic underpinnings of T2D and its cardiovascular complications and leverage multi-omics integration to uncover the...

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Identifiers

PMID: 40241080
DOI: 10.1186/s12933-025-02718-4
PMCID: PMC12004867

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