Article
Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand.
Diabetologia - 1 Jul 2018
Krishnan Mohanraj, Major Tanya J, Topless Ruth K, Dewes Ofa, Yu Lennex, Thompson John M D, McCowan Lesley, de Zoysa Janak, Stamp Lisa K, Dalbeth Nicola, Harré Hindmarsh Jennie, Rapana Nuku, Deka Ranjan, Eng Winston W H, Weeks Daniel E, Minster Ryan L, McGarvey Stephen T, Viali Satupa'itea, Naseri Take, Sefuiva Reupena Muagututi'a, Wilcox Phillip, Grattan David, Shepherd Peter R, Shelling Andrew N, Murphy Rinki, Merriman Tony R
Abstract excerpt
AIMS/HYPOTHESIS: The A (minor) allele of CREBRF rs373863828 has been associated with increased BMI and reduced risk of type 2 diabetes in the Samoan populations of Samoa and American Samoa. Our aim was to test rs373863828 for associations with BMI and the odds of type 2 diabetes, gout and chronic kidney disease (CKD) in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand. METHODS: Linear and...
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