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Article

Genome-wide characterization of 54 urinary metabolites reveals molecular impact of kidney function.

Nature communications - 2 Jan 2025

Valo Erkka, Richmond Anne, Mutter Stefan, Dahlström Emma H, Campbell Archie, Porteous David J, Wilson James F, Groop Per-Henrik, Hayward Caroline, Sandholm Niina

Abstract excerpt

Dissecting the genetic mechanisms underlying urinary metabolite concentrations can provide molecular insights into kidney function and open possibilities for causal assessment of urinary metabolites with risk factors and disease outcomes. Proton nuclear magnetic resonance metabolomics provides a high-throughput means for urinary metabolite profiling, as widely applied for blood biomarker studies. Here we report a...

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PMID: 39746953
DOI: 10.1038/s41467-024-55182-1
PMCID: PMC11696681

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