Article

Endo-Lysosome-Targeted Nanoparticle Delivery of Antiviral Therapy for Coronavirus Infections

2023-05-09

Abstract excerpt

<h4>ABSTRACT</h4> SARS-CoV-2 can infect cells through endocytic uptake, a process which is targeted by inhibition of lysosomal proteases. However, clinically this approach to treat viral infections has afforded mixed results, with some studies detailing an oral regimen of hydroxychloroquine accompanied by significant off-target toxicities. We rationalized that an organelle-targeted approach will avoid toxicity wh...

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Literature Corpus work: 59e08a30-588a-5695-b1d4-46bc4e9eef46
DOI: 10.1101/2023.05.08.539898

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