Article

Lung surfactants as a component of lipid nanoparticles for pulmonary mRNA delivery

2026-05-22

Abstract excerpt

<h4>ABSTRACT</h4> Pulmonary delivery of lipid nanoparticles (LNPs) remains an area of significant interest, given the broad range of genetic disorders that could be addressed through localized administration of therapeutic nucleic acids to the lung. In this study, we investigated how incorporation of the clinically used lung surfactant cocktail Poractant alfa affects the in vitro and in vivo transfection perfor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ac737602-c1a2-5872-8e83-5051062f491f
DOI: 10.64898/2026.05.20.726526

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lung surfactants as a component of lipid nanoparticles for pulmonary mRNA deliveryDOI 10.64898/2026.05.20.726526Read

Peptide additives reprogram the lipid nanoparticle corona and enhance gene delivery in a serum-free environment for lung epitheliumSemantic proximity Read

Optimized inhaled LNP formulation for enhanced treatment of idiopathic pulmonary fibrosis via mRNA-mediated antibody therapySemantic proximity Read

Lipid Nanoparticle Delivery Systems to Enable mRNA-Based TherapeuticsSemantic proximity Read

Intranasal and Pulmonary Lipid Nanoparticles for Gene Delivery: Turning Challenges into OpportunitiesSemantic proximity Read

Unlocking the potential of RNA-based therapeutics in the lung: current status and future directionsSemantic proximity Read

Lipid nanoparticles for delivery of RNA therapeutics: Current status and the role of in vivo imagingSemantic proximity Read

Engineering of mRNA vaccine platform with reduced lipids and enhanced efficacySemantic proximity Read

Exploring Mechanisms of Lipid Nanoparticle-Mucus Interactions in Healthy and Cystic Fibrosis ConditionsSemantic proximity Read

Machine learning engineered PoLixNano nanoparticles overcome delivery barriers for nebulized mRNA therapeuticsSemantic proximity Read

Pulmonary surfactant-based inhalable nanoparticles for folate receptor- targeted delivery and macrophage reprogramming in lung cancerSemantic proximity Read

Reengineering mRNA lipid nanoparticles for systemic delivery to pancreasSemantic proximity Read

Lipid Nanoparticles for In Vivo Lung Delivery of CRISPR-Cas9 Ribonucleoproteins Allow Gene Editing of Clinical TargetsSemantic proximity Read