Article

Hydroxychloroquine decouples reactogenicity from efficacy in mRNA and viral-vector gene delivery

2025-11-11

Abstract excerpt

Programmable nucleic-acid therapeutics, including lipid nanoparticle (LNP)–formulated mRNA vaccines, genome editors delivered as mRNA, and viral vectors, are transforming precision medicine but remain constrained by innate reactogenicity despite the introduction of chemical modifications into mRNA. Here, we show that mRNA/LNPs and viral vectors elicit a transient inflammatory burst that peaks ∼6 h after dosing in...

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Literature Corpus work: 0a9bbea7-656c-5e77-8428-5738930c0bfc
DOI: 10.1101/2025.11.10.687670

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