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Design and Delivery of Therapeutic siRNAs: Application to MERS-Coronavirus

22 Mar 2018

Abstract excerpt

BACKGROUND: The MERS-CoV is a novel human coronavirus causing respiratory syndrome since April 2012. The replication of MERS-CoV is mediated by ORF 1ab and viral gene activity can be modulated by RNAi approach. The inhibition of virus replication has been documented in cell culture against multiple viruses by RNAi approach. Currently, very few siRNA against MERS-CoV have been computationally designed and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29119921
DOI: 10.2174/1381612823666171109112307

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