Article

The ACE-2 receptor accelerates but is not biochemically required for SARS-CoV-2 membrane fusion

2022-10-24

Abstract excerpt

<h4>ABSTRACT</h4> The SARS-CoV-2 coronavirus infects human cells via the ACE-2 receptor. Circumstantial evidence suggests that ACE-2 may not just serve as an attachment factor but also help activate the SARS-CoV-2 spike protein for membrane fusion. Here, we test that hypothesis directly, using DNA-lipid tethering as a synthetic attachment factor in the place of ACE-2. We find that SARS-CoV-2 pseudovirus and virus...

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Literature Corpus work: 59e073cc-ebd9-5ca8-8da8-98731e1b198b
DOI: 10.1101/2022.10.22.513347

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