Article

The inhibitory effect of a Corona virus spike protein fragment with ACE2

2020-06-04

Abstract excerpt

<h4>ABSTRACT</h4> In this paper, we investigate the molecular assembly processes of a Coronavirus Spike protein fragment, the hexapeptide YKYRYL on the ACE2 receptor and its inhibitory effect on the aggregation and activation of the CoV-2 spike receptor protein at the same receptor protein. In agreement with an experimental study, we find a high affinity of the hexapeptide to the binding interface between the spi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 980bf601-aaca-52d5-8725-52f396efe208
DOI: 10.1101/2020.06.03.132506

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The inhibitory effect of a Corona virus spike protein fragment with ACE2DOI 10.1101/2020.06.03.132506Read

The Distal Polybasic Cleavage Sites of SARS-CoV-2 Spike Protein Enhance Spike Protein-ACE2 BindingSemantic proximity Read

Enhanced Binding of SARS-CoV-2 Spike Protein to Receptor by Distal Polybasic Cleavage Sites.Semantic proximity Read

SARS-CoV-2 Spike mutations modify the interaction between virus Spike and human ACE2 receptors.Semantic proximity Read

Computational study of the strong binding mechanism of SARS-CoV-2 spike and ACE2Semantic proximity Read

All-Atom Simulations of Human ACE2-Spike Protein RBD Complexes for SARS-CoV-2 and Some of its Variants: Nature of Interactions and Free Energy Diagrams for Dissociation of the Protein Complexes.Semantic proximity Read

A comprehensive examination of ACE2 receptor and prediction of spike glycoprotein and ACE2 interaction based on in silico analysis of ACE2 receptor.Semantic proximity Read

Investigation of the effect of temperature on the structure of SARS-Cov-2 Spike Protein by Molecular Dynamics SimulationsSemantic proximity Read

Domains and Functions of Spike Protein in Sars-Cov-2 in the Context of Vaccine Design.Semantic proximity Read

Studying the Effects of ACE2 Mutations on the Stability, Dynamics, and Dissociation Process of SARS-CoV‑2 S1/hACE2 ComplexesSemantic proximity Read

Structural Insights Into the Design of Peptide-based Drug or Diagnostic Reagent Antagonizing SARS-COV-2Semantic proximity Read

A comprehensive examination of ACE2 receptor and prediction of spike glycoprotein and ACE2 interaction based on in silico analysis of ACE2 receptorSemantic proximity Read

Binding mechanism of neutralizing Nanobodies targeting SARS-CoV-2 Spike GlycoproteinSemantic proximity Read