Back to search

Article

<i>In silico, in vitro</i> and <i>in cellulo</i> models for monitoring SARS-CoV-2 spike/human ACE2 complex, viral entry and cell fusion

2021-02-03

Abstract excerpt

<h4>ABSTRACT</h4> Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent responsible for the recent coronavirus disease 2019 (COVID-19) pandemic. Productive SARS-CoV-2 infection relies on viral entry into cells expressing angiotensin-converting enzyme 2 (ACE2). Indeed, viral entry into cells is mostly mediated by the early interaction between the viral spike protein S and its ACE2 rec...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e9142e36-03c3-5c59-87ea-8877d1711893
DOI
10.1101/2021.02.03.429555
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
<i>In silico, in vitro</i> and <i>in cellulo</i> models for monitoring SARS-CoV-2 spike/human ACE2 complex, viral entry and cell fusionDOI 10.1101/2021.02.03.429555
In Silico, In Vitro and In Cellulo Models for Monitoring SARS-CoV-2 Spike/Human ACE2 Complex, Viral Entry and Cell FusionSemantic proximity
Single-virus tracking reveals variant SARS-CoV-2 spike proteins induce ACE2-independent membrane interactions.Semantic proximity
Interaction of SARS-CoV-2 with host cells and antibodies: experiment and simulationSemantic proximity
Variations in cell-surface ACE2 levels alter direct binding of SARS-CoV-2 Spike protein and viral infectivity: Implications for measuring Spike protein interactions with animal ACE2 orthologsSemantic proximity
Conversion rate to the secondary conformation state in the binding mode of SARS-CoV-2 spike protein to human ACE2 may predict infectivity efficacy of the underlying virus mutantSemantic proximity
Small-Molecule <i>In Vitro</i> Inhibitors of the Coronavirus Spike – ACE2 Protein-Protein Interaction as Blockers of Viral Attachment and Entry for SARS-CoV-2Semantic proximity
Investigation of Interaction Between the Spike Protein of SARS-CoV-2 and ACE2-Expressing Cells Using an In Vitro Cell Capturing SystemSemantic proximity
Selection of Bis-Indolyl Pyridines and Triphenylamines as New Inhibitors of SARS-CoV-2 Cellular Entry by Modulating the Spike Protein/ACE2 InterfacesSemantic proximity
SARS-CoV-2 Requires Cholesterol for Viral Entry and Pathological Syncytia FormationSemantic proximity
Deletion of ER-retention Motif on SARS-CoV-2 Spike Protein Reduces Cell Hybrid During Cell-cell FusionSemantic proximity
Generation of Spike-Extracellular Vesicles (S-EVs) as a Tool to Mimic SARS-CoV-2 Interaction with Host CellsSemantic proximity
SARS-CoV-2 and SARS-CoV spike-mediated cell-cell fusion differ in the requirements for receptor expression and proteolytic activationSemantic proximity
Select a neighboring publication to make it the new centre.