Article

SARS-CoV-2 Requires Cholesterol for Viral Entry and Pathological Syncytia Formation

2020-12-14

Abstract excerpt

<h4>Summary</h4> Many enveloped viruses induce multinucleated cells (syncytia), reflective of membrane fusion events caused by the same machinery that underlies viral entry. These syncytia are thought to facilitate replication and evasion of the host immune response. Here, we report that co-culture of human cells expressing the receptor ACE2 with cells expressing SARS-CoV-2 spike, results in synapse-like intercel...

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Literature Corpus work: 4483d30d-e00b-57e6-8cb6-daefbfb36a2a
DOI: 10.1101/2020.12.14.422737

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