Article

Single-virus fusion measurements reveal multiple mechanistically equivalent pathways for SARS-CoV-2 entry

2021-05-05

Abstract excerpt

SARS-CoV-2 binds to cell-surface receptors and is activated for membrane fusion and cell entry via proteolytic cleavage. Phenomenological data have shown that SARS-CoV-2 can be activated for entry at either the cell surface or in endosomes, but the relative roles in different cell types and mechanisms of entry have been debated. Here we use single-virus fusion experiments and exogenously controlled proteases to pr...

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Literature Corpus work: 4ed5bbae-8900-57ed-b63b-a5bc4d05bea9
DOI: 10.1101/2021.05.04.442634

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