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Article

Analysis of whole genome sequencing and plasma metabolomics unveil genetic determinants and clinical implications for human health.

Nature communications - 22 Jun 2026

Wang Yi-Xuan, Qiang Yi-Xuan, Ge Yi-Jun, Deng Yue-Ting, Wu Bang-Sheng, Yang Liu, Chen Yi-Lin, He Xiao-Yu, He Yu, Yao Bing-Ran, Fei Chen-Jie, Yin Rui-Ying, You Jia, Feng Jian-Feng, Cheng Wei, Yu Jin-Tai

Abstract excerpt

Blood metabolites are critical biomarkers linking genetic variation to diverse health outcomes, exhibiting significant variability across individuals. Here, we analyze and integrate whole-genome sequencing with plasma metabolomics to investigate the genetic architecture of 313 metabolic biomarkers in up to 199,138 UK Biobank participants. Through single-variant analyses, we identify 36,105 independent signals,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42331824
DOI: 10.1038/s41467-026-74781-8
PMCID: PMC13443626

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