Article

Translation rate prediction and regulatory motif discovery with multi-task learning

2022-05-04

Abstract excerpt

Many studies have found that sequence in the 5’ untranslated regions (UTRs) impacts the translation rate of an mRNA, but the regulatory grammar that underpins this translation regulation remains elusive. Deep learning methods deployed to analyse massive sequencing datasets offer new solutions to motif discovery. However, existing works focused on extracting sequence motifs in individual datasets, which may not be...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 59c74a47-9892-5beb-bb0d-a21a278adb62
DOI: 10.1101/2022.05.03.490410

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Translation rate prediction and regulatory motif discovery with multi-task learningDOI 10.1101/2022.05.03.490410Read

Deep learning modeling of ribosome profiling reveals regulatory underpinnings of translatome and interprets disease variantsSemantic proximity Read

Predicting Mean Ribosome Load for 5’UTR of any length using Deep LearningSemantic proximity Read

Analysis of RNA translation with a deep learning architecture provides new insight into translation controlSemantic proximity Read

Predicting the translation efficiency of messenger RNA in mammalian cellsSemantic proximity Read

Deciphering 3’ UTR mediated gene regulation using interpretable deep representation learningSemantic proximity Read

NeuroTIS+: An Improved Method for Translation Initiation Site Prediction in Full-Length mRNA Sequence via Structural InformationSemantic proximity Read

RNA language models predict mutations that improve RNA function.Semantic proximity Read

Predicting functional consequences of SNPs on mRNA translation via machine learning.Semantic proximity Read

A Suite of Foundation Models Captures the Contextual Interplay Between CodonsSemantic proximity Read

Gene expression is encoded in all parts of a co-evolving interacting gene regulatory structureSemantic proximity Read

Direct analysis of ribosome targeting illuminates thousand-fold regulation of translation initiationSemantic proximity Read

Quantitative model suggests both intrinsic and contextual features contribute to the transcript coding ability determination in cellsSemantic proximity Read