Article

Deep learning modeling of ribosome profiling reveals regulatory underpinnings of translatome and interprets disease variants

2024-03-01

Abstract excerpt

Gene expression involves transcription and translation. Despite large datasets and increasingly powerful methods devoted to calculating genetic variants' effects on transcription, discrepancy between mRNA and protein levels hinders the systematic interpretation of the regulatory effects of disease-associated variants. Accurate models of the sequence determinants of translation are needed to close this gap and to i...

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Literature Corpus work: c6868285-52a8-53a3-bd39-20d3c9ae6114
DOI: 10.1101/2024.02.26.582217

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