Article
RNA language models predict mutations that improve RNA function.
Nature communications - 5 Dec 2024
Shulgina Yekaterina, Trinidad Marena I, Langeberg Conner J, Nisonoff Hunter, Chithrananda Seyone, Skopintsev Petr, Nissley Amos J, Patel Jaymin, Boger Ron S, Shi Honglue, Yoon Peter H, Doherty Erin E, Pande Tara, Iyer Aditya M, Doudna Jennifer A, Cate Jamie H D
Abstract excerpt
Structured RNA lies at the heart of many central biological processes, from gene expression to catalysis. RNA structure prediction is not yet possible due to a lack of high-quality reference data associated with organismal phenotypes that could inform RNA function. We present GARNET (Gtdb Acquired RNa with Environmental Temperatures), a new database for RNA structural and functional analysis anchored to the...
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