Back to search

Article

A protein-trap allele reveals roles for <i>Drosophila</i> ATF4 in photoreceptor degeneration, oocyte maturation and wing development

2021-05-18

Abstract excerpt

Metazoans have evolved various stress response mechanisms to cope with cellular stress inflicted by external and physiological conditions. The Integrated Stress Response (ISR) is an evolutionarily conserved pathway that mediates adaptation to cellular stress via the transcription factor, ATF4. Loss of function of Drosophila ATF4, encoded by the gene cryptocephal ( crc ), results in lethality during pupal develo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
1011ca63-847a-5861-9276-277ad13c1942
DOI
10.1101/2021.05.18.444691
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A protein-trap allele reveals roles for <i>Drosophila</i> ATF4 in photoreceptor degeneration, oocyte maturation and wing developmentDOI 10.1101/2021.05.18.444691
A protein-trap allele reveals roles for Drosophila ATF4 in photoreceptor degeneration, oogenesis and wing development.Semantic proximity
The cryptocephal gene (ATF4) encodes multiple basic-leucine zipper proteins controlling molting and metamorphosis in Drosophila.Semantic proximity
<i>Atf6</i> <sup>-/-</sup> mouse photoreceptors exhibit novel ciliary rootlet defectSemantic proximity
The Endoplasmic Reticulum Proteostasis Regulator ATF6 is Essential for Human Cone Photoreceptor DevelopmentSemantic proximity
Pathomechanisms of ATF6-Associated Cone Photoreceptor Diseases.Semantic proximity
Atf3 links loss of epithelial polarity to defects in cell differentiation and cytoarchitectureSemantic proximity
Structure function analysis of mammalian cryptochromes.Semantic proximity
From Drosophila to humans: reflections on the roles of the prolyl isomerases and chaperones, cyclophilins, in cell function and disease.Semantic proximity
Overexpression of Myocilin in the Drosophila Eye Activates the Unfolded Protein Response: Implications for GlaucomaSemantic proximity
Achromatopsia mutations target sequential steps of ATF6 activation.Semantic proximity
Pathogenic Cx31 is un/misfolded to cause skin abnormality via a Fos/JunB-mediated mechanism.Semantic proximity
Control of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis.Semantic proximity
Select a neighboring publication to make it the new centre.