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RNA Sequence Reveals Mouse Retinal Transcriptome Changes Early after Axonal Injury

27 Mar 2014

Abstract excerpt

Glaucoma is an ocular disease characterized by progressive retinal ganglion cell (RGC) death caused by axonal injury. However, the underlying mechanisms involved in RGC death remain unclear. In this study, we investigated changes in the transcriptome profile following axonal injury in mice (C57BL/6) with RNA sequencing (RNA-seq) technology. The experiment group underwent an optic nerve crush (ONC) procedure to...

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PMID: 24676137
DOI: 10.1371/journal.pone.0093258

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