Article

Multi-omic analysis of photoreceptor alterations during early-onset retinal degeneration in <i> Mfrp <sup>-/-</sup> </i> mice

2025-08-02

Abstract excerpt

<h4>ABSTRACT</h4> Loss-of-function mutations in the membrane frizzled-related protein ( MFRP ) gene are associated with autosomal recessive ocular disorders such as nanophthalmos, posterior microphthalmia, and retinitis pigmentosa, yet the molecular mechanisms underlying MFRP -related retinal degeneration remain poorly defined. To investigate these mechanisms, we generated and characterized Mfrp -/- mice and...

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Literature Corpus work: 33aac59e-e91a-584d-a3de-22ee348474e1
DOI: 10.1101/2025.08.02.668277

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