Article

Evidence for glutamate excitotoxicity that occurs before the onset of striatal cell loss and motor symptoms in an ovine Huntington’s Disease model

2023-06-24

Abstract excerpt

<h4>Background</h4> Huntington’s disease (HD) is a neurodegenerative genetic disorder caused by an expansion in the CAG repeat tract of the huntingtin ( HTT ) gene resulting in a triad of behavioural, cognitive, and motor defects. Current knowledge of disease pathogenesis remains incomplete, and no disease course-modifying interventions are in clinical use. We have previously reported the development and charact...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 59b6f2f1-9376-5d12-a47f-db8332af515e
DOI: 10.1101/2023.06.20.545648

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evidence for glutamate excitotoxicity that occurs before the onset of striatal cell loss and motor symptoms in an ovine Huntington’s Disease modelDOI 10.1101/2023.06.20.545648Read

From Pathogenesis to Therapeutics: A Review of 150 Years of Huntington’s Disease ResearchSemantic proximity Read

Further Molecular Characterisation of the OVT73 Transgenic Sheep Model of Huntington's Disease Identifies Cortical AggregatesSemantic proximity Read

Molecular Strategies for the Treatment of Huntington's Disease.Semantic proximity Read

Huntington disease: a single-gene degenerative disorder of the striatumSemantic proximity Read

The Caudate Nucleus Undergoes Dramatic and Unique Transcriptional Changes in Human Prodromal Huntington’s Disease BrainSemantic proximity Read

Oxidative damage in Huntington's disease pathogenesis.Semantic proximity Read

Pathophysiology of Huntingtonʼs disease: from huntingtin functions to potential treatmentsSemantic proximity Read

In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons.Semantic proximity Read

snRNA-seq of Huntington’s disease mice reveals vulnerability profiles of cortical cell typesSemantic proximity Read

The molecular biology of Huntington's disease.Semantic proximity Read

Therapeutics Advancement for Huntington DiseaseSemantic proximity Read

Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease.Semantic proximity Read