Article

Molecular Strategies for the Treatment of Huntington's Disease.

2004-09-01

Abstract excerpt

Huntington's disease (HD) is a devastating neurodegenerative disorder for which there is no effective treatment yet. The disease presents motor, psychiatric and cognitive symptoms, and it is caused by the expansion of CAG repeats in the huntingtin (htt) gene, which codes for a polyglutamine tract in the htt protein. The repeat expansion causes the preferential degeneration of the medium spiny neurons in the caudat...

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Literature Corpus work: ec493f65-2d7a-52e3-a6fe-f6ada9671b49
DOI: 10.2174/1570160043377475

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