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Article

The molecular biology of Huntington's disease.

Psychological medicine - 1 Jan 2001

Ho L W, Carmichael J, Swartz J, Wyttenbach A, Rankin J, Rubinsztein D C

Abstract excerpt

BACKGROUND: Huntington's disease (HD) is a fatal neurodegenerative disorder with an autosomal dominant mode of inheritance. It leads to progressive dementia, psychiatric symptoms and an incapacitating choreiform movement disorder, culminating in premature death. HD is caused by an increased CAG repeat number in a gene coding for a protein with unknown function, called huntingtin. The trinucleotide CAG codes for...

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PMID: 11200958
DOI: 10.1017/s0033291799002871

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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