Article

SynGAP splice isoforms differentially regulate synaptic plasticity and dendritic development

2020-01-28

Abstract excerpt

<h4>Summary</h4> SynGAP is a synaptic Ras GTPase-activating protein (GAP) with four C-terminal splice variants: α1, α2, β, and γ. Although recent studies have implicated SYNGAP1 haploinsufficiency in ID/ASD pathogenesis, the degree to which each SynGAP isoform contributes to disease pathogenesis remains elusive. Here we demonstrate that individual SynGAP isoforms exhibit unique spatiotemporal expression and have...

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Literature Corpus work: 9b018d6b-6bc4-50a7-ba56-2543f5e90df4
DOI: 10.1101/2020.01.28.922013

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