Article

Mitochondrial damage triggers therapy-induced senescence

2024-12-21

Abstract excerpt

Glioblastoma (GBM) is a fatal brain tumor with a critical need for better therapies. It is known that the PI3K, MAPK, and CDK4/6 signaling pathways are hyper-activated in these tumors; however, previous studies have used very high concentration of inhibitors to assess their importance, with mixed results. Here we developed PMCi, a combination approach that targets all three pathways simultaneously, at clinically-r...

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Literature Corpus work: 0a6e1a23-530c-5087-bcf2-b656935ca4be
DOI: 10.1101/2024.12.20.629667

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