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Article

Bromodeoxyuridine Inhibits Cancer Cell Proliferation In Vitro and In Vivo

1 Aug 2008

Abstract excerpt

The thymidine analog bromodeoxyuridine (BrdU) is incorporated into newly synthesized DNA and has been shown to increase the susceptibility of incorporating cells to ionizing radiation. However, in the absence of secondary stressors, BrdU is thought to substitute relatively benignly for thymidine and is commonly used to "birth-date" proliferative cells. We report a novel antiproliferative effect of BrdU on cancer...

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PMID: 18680882
DOI: 10.1593/neo.08382

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