Activation of p53 by nutlin-3a induces apoptosis and cellular senescence in human glioblastoma multiforme.

Abstract excerpt

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults. Despite concerted efforts to improve current therapies and develop novel clinical approaches, patient survival remains poor. As such, increasing attention has focused on developing new therapeutic strategies that specifically target the apoptotic pathway in order to improve treatment responses. Recently, nutlins,...

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