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Is Senescence Reversible?

26 Aug 2015

Abstract excerpt

Senescence was originally identified by the finite lifespan of normal cells that is a consequence of telomere shortening with each cycle of DNA replication. Cells undergoing replicative senescence display pronounced morphological and biochemical changes such as flattening and/or enlargement, increases in p21(WAF1) and/or p16(INK4A), a senescence-associated secretory phenotype, and often senescence-associated...

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PMID: 26302802
DOI: 10.2174/1389450116666150825113500

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