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Article

Species and subtype variants of the N-formyl peptide chemotactic receptor reveal multiple important functional domains.

The Journal of biological chemistry - 5 Dec 1993

Gao J L, Murphy P M

Abstract excerpt

The N-formyl peptide receptor (FPR) is a seven transmembrane-domain receptor that mediates trafficking and activation of phagocytic leukocytes in response to N-formyl oligopeptides such as fMet-Leu-Phe. cDNAs for high affinity FPRs have been cloned from both human (huFPR) and rabbit (rabFPR). To identify functional domains of FPR, we have studied two structurally related "natural mutants" that are 100-10,000-fold...

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PMID: 8244972

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