Article

Lowering hippocampal miR-29a expression slows cognitive decline and reduces beta-amyloid deposition in 5xFAD mice

2023-08-16

Abstract excerpt

<title>Abstract</title> <p>microRNA-29a (miR-29a) increases with age in humans and mice, and, in the brain, it has a role in neuronal maturation and response to inflammation. We previously associated higher miR-29a levels in human brain with faster antemortem cognitive decline, suggesting that lowering miR-29a levels could ameliorate memory impairment in the 5xFAD AD mouse model. To test this hypothesis, we gener...

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Literature Corpus work: 3fea44fc-e444-5b14-9e0f-3c864dcb1edf
DOI: 10.21203/rs.3.rs-3235257/v1

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