Article

Ultrasound-Mediated Gene Therapy in Alzheimer’s Disease Validated through In Vivo PET Imaging

2026-02-04

Abstract excerpt

Efficient, spatially selective delivery of adeno-associated virus (AAV) therapeutics to deep brain structures remains a major challenge to gene therapy for Alzheimer’s disease (AD), owing to limited transport across the blood-brain barrier (BBB) and poor penetration to target neurons. Here, we establish an integrated, noninvasive imaging and therapy platform that combines microbubble-enhanced focused ultrasound (M...

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Literature Corpus work: 37dff890-6ae8-5e04-b88e-11ba06403659
DOI: 10.64898/2026.02.02.703398

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