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Article

An empirical investigation into the impact of winner's curse on estimates from Mendelian randomization.

International journal of epidemiology - 2 Aug 2023

Jiang Tao, Gill Dipender, Butterworth Adam S, Burgess Stephen

Abstract excerpt

INTRODUCTION: Genetic associations for variants identified through genome-wide association studies (GWASs) tend to be overestimated in the original discovery data set as, if the association was underestimated, the variant may not have been detected. This bias, known as winner's curse, can affect Mendelian randomization estimates, but its severity and potential impact are unclear. METHODS: We performed an...

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Identifiers

PMID: 36573802
DOI: 10.1093/ije/dyac233
PMCID: PMC10396423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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