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Article

Impaired glycolysis in aged endothelial cells is associated with reduced neovascularisation upon tissue ischemia

2024-01-27

Abstract excerpt

<h4>ABSTRACT</h4> The vascular system experiences an age-associated decline in tissue perfusion and response to ischemic diseases. The factors driving this age-associated neovascularization decline remain unclear. While old endothelial cells (ECs) adopt a pro-angiogenic gene expression profile, we observed a stark reduction in the proliferative capacity of old ECs, while migratory capabilities remain intact. This...

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Literature Corpus work
5882368e-5ae7-5f6c-b959-925f6c64dbf5
DOI
10.1101/2024.01.26.577495
Open publication

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Impaired glycolysis in aged endothelial cells is associated with reduced neovascularisation upon tissue ischemiaDOI 10.1101/2024.01.26.577495
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