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Functional Characterisation and Drug Target Validation of a Mitotic Kinesin-13 in Trypanosoma brucei

19 Aug 2010

Abstract excerpt

Mitotic kinesins are essential for faithful chromosome segregation and cell proliferation. Therefore, in humans, kinesin motor proteins have been identified as anti-cancer drug targets and small molecule inhibitors are now tested in clinical studies. Phylogenetic analyses have assigned five of the approximately fifty kinesin motor proteins coded by Trypanosoma brucei genome to the Kinesin-13 family. Kinesins of...

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PMID: 20808899
DOI: 10.1371/journal.ppat.1001050

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