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A high-throughput protein tagging toolkit that retains endogenous untranslated regions for studying gene regulation in kinetoplastids

1 Feb 2025

Abstract excerpt

Kinetoplastid parasites cause diseases that threaten human and animal health. To survive transitions between vertebrate hosts and insect vectors, these parasites rely on precise regulation of gene expression to adapt to environmental changes. Since gene regulation in kinetoplastids is primarily post-transcriptional, developing efficient genetic tools for modifying genes at their endogenous loci while preserving...

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PMID: 39999874
DOI: 10.1098/rsob.240334

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