Article

<i>Trypanosoma cruzi</i> VDU deubiquitinase mediates surface protein trafficking and infectivity

2023-04-17

Abstract excerpt

Ubiquitylation is a post-translational modification promoting protein degradation. Within the endomembrane system ubiquitylation marks proteins for lysosomal processing. Deubiquitinases (DUBs) cleave ubiquitin from modified proteins and, in the case of surface proteins, prevent lysosomal targeting and thus play a major role in controlling turnover. In Trypanosoma cruzi, the etiological agent of Chagas disease, ac...

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Literature Corpus work: 228bc64d-3e06-57d1-bd0f-bc0a8ddc2039
DOI: 10.1101/2023.04.17.537123

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