Article
Multiple domains of the integral KREPA3 protein are critical for the structure and precise functions of RNA editing catalytic complexes in Trypanosoma brucei.
RNA (New York, N.Y.) - 1 Oct 2023
Davidge Brittney, McDermott Suzanne M, Carnes Jason, Lewis Isaac, Tracy Maxwell, Stuart Kenneth D
Abstract excerpt
The gRNA directed U-insertion and deletion editing of mitochondrial mRNAs that is essential in different life-cycle stages for the protozoan parasite Trypanosoma brucei is performed by three similar multiprotein catalytic complexes (CCs) that contain the requisite enzymes. These CCs also contain a common set of eight proteins that have no apparent direct catalytic function, including six that have an OB-fold...
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