Article
Interstitial Fluid Shear Stress Induces the Synthetic Phenotype Switching of VSMCs to Release Pro-calcified Extracellular Vesicles via EGFR-MAPK-KLF5 Pathway.
International journal of biological sciences - 1 Jan 2024
Gao Wenbo, Gu Kaiyun, Ma Lunjie, Yang Fan, Deng Li, Zhang Yaojia, Miao Michael Z, Li Wenjun, Li Gang, Qian Hong, Zhang Zhen, Wang Guixue, Yu Hongchi, Liu Xiaoheng
Abstract excerpt
Phenotypic switching (from contractile to synthetic) of vascular smooth muscle cells (VSMCs) is essential in the progression of atherosclerosis. The damaged endothelium in the atherosclerotic artery exposes VSMCs to increased interstitial fluid shear stress (IFSS). However, the precise mechanisms by which increased IFSS influences VSMCs phenotypic switching are unrevealed. Here, we employed advanced numerical...
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