Article

Typing the tumor immune signatures in patients of Lynch syndrome facilitates predicting the responsiveness of immune checkpoint inhibition

2022-08-09

Abstract excerpt

<h4>Background: </h4> Although many efforts of predicting the responsiveness to immune checkpoint inhibition including expression of PD-L1 and MHC I, microsatellite instability (MSI), mismatch repair (MMR) defect, tumor mutation burden (TMB), tertiary lymphoid structures (TLSs) and several transcriptional signatures have been performed, the sensitivity remains to be further improved. <h4>Methods and Results: </h4>...

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Literature Corpus work: 59291c26-623e-5489-9268-2c979639be4a
DOI: 10.21203/rs.3.rs-1932907/v1

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