Article
Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF.
Scientific reports - 3 Nov 2021
Monkley Susan, Overed-Sayer Catherine, Parfrey Helen, Rassl Doris, Crowther Damian, Escudero-Ibarz Leire, Davis Nicola, Carruthers Alan, Berks Richard, Coetzee Marisa, Kolosionek Ewa, Karlsson Maria, Griffin Leia R, Clausen Maryam, Belfield Graham, Hogaboam Cory M, Murray Lynne A
Abstract excerpt
The unfolded protein response (UPR) is a direct consequence of cellular endoplasmic reticulum (ER) stress and a key disease driving mechanism in IPF. The resolution of the UPR is directed by PPP1R15A (GADD34) and leads to the restoration of normal ribosomal activity. While the role of PPP1R15A has been explored in lung epithelial cells, the role of this UPR resolving factor has yet to be explored in lung...
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