Article

Plasma membrane rather than endosomal Gq signaling drives transcriptional activity by the viral chemokine receptor US28 in glioblastoma

2025-06-15

Abstract excerpt

<h4>ABSTRACT</h4> US28 is a human cytomegalovirus-encoded chemokine receptor homologue that has high agonist-independent activity, internalizes constitutively, and plays an oncomodulatory role in glioblastoma. As G protein signaling was originally believed to strictly occur at the plasma membrane, it has been assumed that US28’s constitutive Gα q/11 signaling is mediated by a minor population at the plasma membr...

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Literature Corpus work: 5908d9ab-b570-5abf-9745-2be2c70f121a
DOI: 10.1101/2025.06.12.659276

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