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Article

Human cytomegalovirus-encoded chemokine receptor US28 promotes tumorigenesis.

Proceedings of the National Academy of Sciences of the United States of America - 29 Aug 2006

Maussang David, Verzijl Dennis, van Walsum Marijke, Leurs Rob, Holl Jens, Pleskoff Olivier, Michel Detlef, van Dongen Guus A M S, Smit Martine J

Abstract excerpt

Human cytomegalovirus (HCMV) is a widely spread herpesvirus, suggested to play a role in tumor progression. US28, a chemokine receptor encoded by HCMV, binds a broad spectrum of chemokines and constitutively activates various pathways linked to proliferation. Our studies reveal that expression of US28 induces a proangiogenic and transformed phenotype by up-regulating the expression of vascular endothelial growth...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16924106
DOI: 10.1073/pnas.0604433103
PMCID: PMC1559754

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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